Todd has been helping buy side portfolio managers as an independent researcher for over a decade. The market reacted to their every peep, and there's a good chance that several of these stocks will have another bumper crop year in 2021. Single-strand RNA copies of DNA tasked with making proteins are usually made without a hitch, but sometimes the genetic instructions for making a protein are incorrect because of mutations. Myriad Genetics' roots are in testing for hereditary forms of cancer, such as breast cancer and ovarian cancer caused by a mutation in the BRCA gene. To spot genetic mutations, researchers must sequence, or screen, a person's genetic material and then compare it to a baseline. Sales jumped 117% year over year to $148 million in 2018, and in 2019, it's targeting revenue of $220 million. Genetics is a high tech, research-intensive business. Inovio Pharmaceuticals (NASDAQ:INO) grew by 173% this year thanks to its coronavirus vaccine program. Learn how to invest in marijuana stocks … It also offers genetic testing for a handful of hereditary cancers and … There's every indication that its vaccine will be a big moneymaker, potentially to the tune of $32 billion in 2021. For example, it's already filed for European approval of LentiGlobin, a gene therapy for transfusion-dependent β-thalassemia, an inherited blood disease that can result in severe anemia. LentiGlobin could eliminate the need for a lifetime of transfusions by inserting a functional human beta-globin gene into the DNA of a patient's blood stem cells. Studies are also evaluating LentiGlobin's potential in sickle cell disease, a life-threatening blood disorder.Â. The traditional genetic testing market is growing in volume and growing in the breadth of tests creating a new life for the industry. Novartis' Kymriah is also approved for use in adults with certain blood cancers that fail to respond to other treatment options. Its sales totaled $76 million in 2018, including $28 million in the fourth quarter. Yescarta's sales were $284 million in 2018, including $81 million in the fourth quarter.Â. His interests include exploring his hometown of Boston, traveling in Latin America, and value investing. Its sales jumped 82% to $90.6 million in 2018. Further investment in expanding its market penetration with these products will help to keep the company's momentum next year and beyond. Still, its coronavirus programs need to be proven definitively in clinical trials next year if its stock is to grow any further, and doubts remain about the viability of its DNA-based vaccines. Thermo Fisher doesn't break out exactly how much money its sequencers contribute to its top line, but its life sciences revenue increased 9% to $6.27 billion in 2018, accounting for 26% of the company's $24.4 billion in total sales. GENE Stock Alert: 10 Things to Know About Genetic Technologies As Shares Rocket Higher Jan. 21, 2021 at 10:18 a.m. Using a blood test, Guardant's solution can identify genetic mutations with similar accuracy to more invasive tissue biopsies obtained via needles. The news of the award helped major gene editing stocks like CRISPR Therapeutics AG CRSP rise 11.4% on Oct 7, as Charpentier is one of the co-founders of the company. Shares of NeoGenomics (NASDAQ: NEO) fell nearly 15%, while shares of Exact … Request a sample kit today Gene sequencing is already contributing to the development of better, more targeted, and potentially safer medicines. Agilent Technologies. As gene-sequencing prices drop, drug developers can use it to create ever more personalized medicine, and people will be able to use it to gain a deeper understanding of themselves via their genetic profile. These broad types of diagnostic testing have the largest share of the genetics market, which also includes prenatal tests, tests to see how a person will respond to certain drugs and targeted tests for specific genetic conditions. Technological limits at the time made fragmenting and reassembly necessary, but this sequencing approach is unable to sequence complex genes, including those with particularly long repeats of genetic code. Whether its first earnings reports in the new year will herald a reckoning is anyone's guess. Nonetheless, in the long-term its older pipeline projects will start to come to fruition. The current value of the portfolio assumes that $1,428.57 was invested (total of $10,000) in each stock … There's more to the company than its coronavirus tests, however. Luxturna restores vision by using a deactivated virus to deliver a normal copy of a missing gene, RPE65, directly to cells in the retina. The acquisition also landed Roche a promising gene therapy for hemophilia A, SPK-8011, which attempts to restore production of a critical missing clotting factor that otherwise leaves patients exposed to the risk of uncontrollable bleeding. Stock Advisor launched in February of 2002. In the meantime, investors can look forward to the next quarterly earnings report, which almost certainly will have even more good news. If you're interested in investing, the only thing to do at the moment is to watch for clinical trial updates to see how its core project is advancing. With quarterly revenue growth exceeding 52,559% year over year, it's easy to see why the market was so enthusiastic about the company. That might change next year if its vaccine is proven effective. Others, like its cytomegalovirus vaccine, may not make a big splash. Demand for NovaSeq has been robust, reaching $1 billion in shipments in just two years. Portfolio values are computed using monthly closes for stocks from Alpha Vantage. The company markets genetic screening tests that can be used by doctors to figure out the best treatment to use in lung cancer and by drugmakers to identify patients likely to respond to gene therapies in clinical trials. Hereditary cancer tests accounted for almost 100% of revenue in 2013; however, they've fallen to about 25% of revenue in 2018 as more tests have been introduced, including GeneSight, a test for determining the best drugs for patients with depression, and prenatal screening tests for genetic disorders. RNA can be ribosomal RNA (rRNA), which makes a specific protein; messenger RNA (mRNA), which delivers instructions on how to build a protein; or transfer RNA (tRNA), which transports the raw material necessary for making a protein. There are about 3 billion base pairs containing instructions necessary for human existence, and there are an estimated 30,000 genes, each responsible for making an average of three proteins. The short-read sequencers used in the human genome project generated about 500 to 800 base pairs per run, so when repeats exceeded that size, gaps were left -- which is why the project was declared complete after 99%, rather than 100%, of the genome was sequenced. Moving forward, it will penetrate foreign markets like India, selling tens of millions of its molecular test kits in the process. Seattle Genetics is first on … Cumulative Growth of a $10,000 Investment in Stock Advisor, eliminate the need for a lifetime of transfusions, it paid $2.4 billion to acquire Foundation Medicine, offer low-cost comprehensive genetic screening to everyone, Copyright, Trademark and Patent Information. About 80% of the estimated 350 million people worldwide with rare diseases are caused by a faulty gene, according to nonprofit Global Genes. As the gene-testing … Given how many hopes were riding on its coronavirus vaccine candidate, you shouldn't be surprised to see Moderna (NASDAQ:MRNA) on this list. Market data powered by FactSet and Web Financial Group. Formerly a researcher in the biotech industry, he leverages his science background in his work as a writer and entrepreneur. The human genome was first sequenced by the U.S. government's Human Genome Project, which was announced in 1988 and funded by Congress in 1990. Some of these applications are better suited to short- or long-read sequencing. Afterwards, a computer reassembled the results back into their longer sequence using the reference library. But the program wrapped up in 2003, when 99% of the genome was sequenced, at a total cost of $2.7 billion. They also sell consumables that are used each time a gene sequence is done. For example, long-read makes sense for complex organisms with little reference data, while short-read is best for analysis of DNA fragments. Gene therapies developed by these biotechnology companies may seek to shut off (or knock down) a gene's production of a gene, sidestep the mutation causing the genetic disease, or edit the gene to restore normal protein production. Some of those tests … Until this year, that is. Genetic testing is soaring, and so are these stocks, writes Michael Brush. A recent clinical update showed that its candidate might not be as protective as the other mRNA vaccines that are already approved for sale. Plus, its $2.74 million in debt barely holds a candle to its trailing revenue in excess of $135 million. A far more diversified company, Thermo Fisher got into the gene-sequencing business with its $13.6 billion acquisition of Life Technologies in 2014. Here's what you need to know about the industry, how it's changing, and the top gene-sequencing stocks worth owning. Genetic testing specialist Fulgent has seen its revenue and bottom line skyrocket. In 2003, Todd founded E.B. Long-read sequencing machines can produce reads of 15,000 base pairs on average, and up to 100,000 base pairs under ideal circumstances, helping researchers overcome the obstacle that long repeats present to short-read sequencing. In mid-December, it announced that the government had taken an interest in developing a DNA-encoded monoclonal antibody therapy for COVID-19 using the company's technology. Illumina estimates less than 0.1% of species, 0.02% of humans, and 1% of human variants have been genetically sequenced so far. Investors should also keep an eye on progress being made in gene editing. Investors interested in gene therapy may also want to consider Celgene (NASDAQ:CELG), which was recently acquired by Bristol-Myers Squibb (NYSE:BMY); bluebird bio (NASDAQ:BLUE); Roche Holdings (OTC:RHHBY); and Regenxbio (NASDAQ:RGNX). Not only has it become the leader in gene sequencing, but it's also opened the field up to more researchers: It's driven the cost of gene sequencing down from the multibillions spent by the Human Genome Project two decades ago to about $1,000 now.. And following the 2017 launch of its latest system, NovaSeq, the company thinks the cost of sequencing could eventually drop to $100, opening up the door for a flood of research that was previously believed to be too expensive to justify. The prospect of using our DNA to inform healthcare decisions is so significant that new players are flocking to this emerging industry all the time. Its liquid biopsy is already winning converts. 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